I only have respect for the cheese of four careers in destruction right now (I'm a snob, what can I say), lol.
Main: Masque (Chaos Zealot... only the best destr. healers EVER)
ALT: Wazdakka (Black Orc... the best destr. tank)
ALT: Kiaransalee (Dark Elf Sorceress... the best of our crappy choices for destr. ranged dps)
ALT: Doombreed (Chaos Marauder... best destr. H2H dps, hands-down)
Not that I'm putting down the other classes available, I'm just a big fan of efficiency and these are focused classes.
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"The reason the American Army does so well in wartime is that war is chaos, and the American Army practices it on a daily basis."
- from a post-war debriefing of a German General